Rare genetic defect caused by coronary heart disease found.

<P> U.S. and Iranian scientists discovered a rare early-onset coronary heart disease can cause genetic defects, a finding that opens up for exploring the pathogenesis of heart disease, a new way. .</ P> <P> According to the latest issue of the U.S. "Science" magazine, Yale University and Amir Kabir University of Iran's cooperation with scientists and other institutions, a large family of the Iranian family of genetic diseases were studied. .This large family of long-term high blood pressure caused by genetic factors, and diabetes and other disease problems, and its members has also been a long fight with premature coronary heart disease. .Premature coronary heart disease before the age of 55 refers to male and female coronary heart disease occurring before the age of 65. .</ P> <P> responsible for the research scientist Richard Lifton of Yale University, said: "We the members of this family identified a specific genetic variation, and identified the specific gene defects leading to mutations. ."Research shows that the gene defect would have a variety of risk factors for metabolic syndrome have a major impact. .Metabolic syndrome showed a variety of metabolic abnormalities exist in an individual, including hypertension, hyperlipidemia and diabetes. .Earlier studies have shown that metabolic syndrome can lead to premature coronary heart disease. .Scientists believe that this newly discovered gene defect may be related to the pathogenesis of premature coronary heart disease. .</ P> <P> the scientists of this large family of Iran, the vast majority of the members have the genetic defect in early 50s died of a sudden heart attack or heart failure. .Lifton noted that several major coronary heart disease is the leading cause of death of human, new study results, while the incidence of coronary heart disease is no reason for all the detailed explanations given, but as the family of coronary heart disease to determine the specific causes of genetic defects, will study .the pathogenesis of other types of heart disease provide valuable clues. .</ P> </ p>.