My first discovery of a new human leukocyte antigen HLA alleles

For the unrelated to increase the success rate of transplantation receptor

Kenilworth (correspondents zhangguoqing) PLA 307 hospital Immunology Institute under the auspices of the XI Yongzhi researcher of ABC, the recent discovery of an hla (HLA) allele, hla has now been officially named Committee who named a * 110104. This is the only country in the entry, unrelated donor transplantation receptor exponentially, bringing increased hematopoietic transplantation in the ligand success rate and accuracy.

Detection and identification of crowd HLA is currently internationally hla research hotspot, as this new gene appears in two different provinces two different families, so they have more important practical value. XI Yongzhi engaged in research and transplantation hla typing over the years, under his guidance, Sun Yuying associate researcher and research group in a Leukemia patients do hematopoietic stem cell transplantation in the ligand, he found his brother hla-a sites have a gene cannot confirm that made a series of studies or to distinguish clearly the identity, and the gene into the international gene banks, retrieval, and still can't find this same gene, feel this most likely is the gene family in new members. To this end, they made a special trip to patients taking his father back home Shanxi blood samples, test and found this gene and the same gene in patients with father, for parent-child two generations genetic. Coincidentally, they provide another patients do matching, discovered a gene donor cannot confirm that they have to pull up his Anhui in patients with their parents, grandparents of blood samples, confirmed by the detection of three generations of the genetic and the gene in patients with Shanxi and this control, as a result both of gene donors, and have a family of hereditary. After the international gene banks and identification of the gene to the same new alleles.

XI Yongzhi describes, in a crowd hla genes appear higher the frequency, the greater their value. This new discovery of value is the Chinese people have a certain frequency and universality, so that you can use for others. To make the organ, and haematopoietic stem cell transplantation for more accurate typing, effectively prevent graft rejection occurs and extend the lives of patients. In particular, China has entered a child age, unrelated donor transplantation receptor found surging, hla identical genes that can be increasing hematopoietic stem cell transplantation in the ligand success rate and accuracy. At the same time this new alleles, also can be widely used in forensic medicine, human research on ethnic migration, etc.