Keywords: United States-specific gene AIDS immunity
The "Edit" gene will access AIDS immunity
According to the United States the Wired Magazine Web site reported, AIDS is still an incurable disease cannot be fully cured, but scientists previously found someone born with HIV antibodies. United States scientists said, through the "Edit" in the body of certain genes, they currently have found a can make everyone get AIDS immunity.
United States University of Pennsylvania · Joan of scientist Carl said they currently grace have found you can save mankind have AIDS immunity of new methods, which marked the human future expected to completely get rid of AIDS. Karl · Joan en that viruses once inside human cells, will take over the cells of all features of normal function of the body affected and destruction. But before the virus into cells, it must locate an appropriate carrier. HIV virus are usually attached to the CCR5 protein above normal and entering human cells. CCR5 protein major coverage to T cells. T cell in the body is two main types of white blood cells of human immune system and resist infection capability functions play a crucial role. The 1990s, researchers have made a special set of gay men. This group of gay men's special in that their HIV test positive for male sexual partners maintain long-term relationships, but have never been infected.
Researchers believe that is because these special gay men in vivo gene mutation has occurred. Gene mutation causes human cells no longer produce normal CCR5 protein, the HIV virus and therefore there is nothing you can enter the body cells of the carrier. Based on this new awareness, scientists test a variety of techniques and methods that you want to be able to hinder the CCR5 protein in normal production or change the CCR5 protein shape makes HIV virus cannot be attached to it. This makes it possible to block HIV virus invasion. This is the "gene editing" technology in the field of AIDS research.
Researchers also found that the AIDS virus and the smallpox virus is delivered through a "chemically active receptor" bio-lock "in the body's immune cells. The protection of the human body defense function of "bio-lock" is appended to the immune system cell surface proteins. Once you have a "foreign" intrusion, these proteins will signal that the mobilization of white blood cells for defense. But AIDS virus and Variola Virus but have compromised the biological "locks" extraordinary ability, they are in the "lock no longer function after penetrate the body's immune system. He takes a name of "zinc finger protein nucleic acid enzymes" (i.e. the zinc finger protein), to split the CCR5 surface of T cells. Zinc finger protein contains a nuclease, adhesion with gene and gene permanently open or closed. For the HIV virus, not the CCR5 protein of T cells, almost difficult to penetrate.
However, Joan's all experiments are in certain cells and mice of achieved success, not human subjects. Therefore, the results of this experiment can only maintain a cautious optimism, it does not demonstrate the technical results to humans as a success. Of course, this technology is in theory possible. Doctors from HIV infection to extract part of T cells in the body, these cells to re-edit of a gene, then implanted into the patient. Once you return to the human body, these genetically edited antibody cell will quickly split, regeneration and diffusion, and no longer be affected by viruses and suppression. Of course, the antibody cell growth and proliferation and cannot eliminate the HIV virus, but guarantees that AIDS the body's T cells, steady growth, enhance their secondary infection of resistance, to maintain their health and lives.
Prior to this, researchers have found that about 1% of Caucasian, its genetic gene has no such biological "locks", is the world's natural immunity to AIDS with the lucky people. Now smallpox has been human conquer, researchers of this new discovery gave people added to conquer AIDS hope.
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