Socio-economic status of people seem to have social elites old fast. They study found that poor telomeric short and telomeric played on chromosomes. As a result and at the same age as compared to the top of the community, the poor man's physiological age to old age.
London, St. Thomas Hospital of Tim-inter-racial grams, is in charge of the research project, he said that "social status not only affects the health and age-related diseases, it seems that it's aging process has significant influence. ”
In order to identify the social status and the relationship between aging, researchers recruited 1552 female twins to experiment, aged from 18 to 75 years old. According to the United Kingdom NSO socio-economic categories, they are divided between five different social classes. Scientists from volunteers who take blood samples for genetic experimentation, observation of chromosomes in their blood. The scientists compared the each test personnel Telomere length of chromosomes. Telomeric is located on chromosome ends on protein structure, it has played on the chromosomes. It is from the manufacture of telomerase. As the cell constant split Telomere length will have been reduced, when it is reduced to a certain length, the cell will no longer be able to copy and dying. Therefore shorter Telomeres chromosome indicate a person's physiological age.
Researchers excludes income, smoking, weight and exercise, and other factors, these factors have an impact on aging well. Scientists found that the economic situation of the poor women of telomeric to short number. And on top of the same age, poor compared to those of Telomere Length shortening of degree equivalent to aging for seven years, this means that the poor of physiological age to old 7-year-old. Researchers put their results published in the journal cell senescence, also pointed out that this phenomenon cannot be attributed to differences in education and income.
Researchers believe that in the society leads to insecurity and inferiority. But this kind of psychological and throws a lot of pressure. Too much pressure may increase cell damage, accelerating the natural aging process of the human body.
Spijk, at a press conference that "this is the equivalent of physiological age 7 years. "He added," this difference appears in the same age, same shape, same smoking status, the same exercise crowd, their only difference is that someone engaged in manual work, it was engaged in non-manual workers. Whereas the work and different results in their social status. ”
Researchers also on 17 Twin Sisters of chromosome Telomere length. This 17 twin sisters at first social status, but mainly because marriage is different, their social status has changed. 12 people because social status changes, the chromosome Telomere Length is shorter, equivalent to 9 years old. This indicates that the social status of the change on chromosome shorter Telomeres.
Spijk, suspected of socio-economic status of telomeric vitality. He said, "we believe that psychological pressure or runaway may be physiological effects. It will increase oxidative stress, make cells more quickly. ”
Oxidative stress on cells and genes produce damaging effects, but the body free radicals is oxidation important indicators high or low pressure. Free radicals with a high degree of oxidation activity they very unstable, the activity is very high, they attack the cell membrane, mitochondrial membrane, and membranes of unsaturated fatty acid reaction, resulting in enhanced lipid peroxidation. Lipid peroxidation products (mda, etc.) can be broken down into more free radicals that cause a chain reaction of free radicals. In this way, the integrity of membrane structure were damaged, causing muscle, liver cells, mitochondrial DNA, RNA, and so extensive damage causing inflammatory diseases such as cancer, dilated cardiomyopathy, senile cataract asthma and other disorders. The free radicals in the body is the disease, aging and death of direct participation and manufacturer.
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