Saturday, January 1, 2011
Japan culture "universal cell" does not touch on the ethical issues
Kyoto Univ. of researchers in the latest issue of nature · methodology "magazine published papers that they are not easy to throw out the rejection of the" universal cell ", because this method only uses somatic and existing embryonic stem cells, therefore fundamental ethical questions are not touched. Differentiation of embryonic stem cells have a variety of tissues and organs, is the "universal cell". However, the culture of embryonic stem cells rely on fertilized eggs or cloning technology, these are the ethical issues. Against this background, the Kyoto University regeneration Medicine researchers consider existing embryonic stem cells and somatic fusion with its own culture of "universal cell", not to destroy the new fertilized eggs. However, such a method of operation of the "universal fusion cells", also remnants from embryonic stem cells of genetic information, still have raised the possibility of rejection. For this, researchers have developed a special kind of DNA fragments, this snippet to remove the chromosome of embryonic stem cells. In animal experiments, researchers take hybrid DNA fragments and embryonic stem cells, then let the embryonic stem cells and experimental rat thymic cell fusion. After two cell fusion through enzyme treatment, will be able to get rid of embryonic stem cell chromosomes and genes of the above. Experimental use of embryonic stem cells have 40 chromosome, this stage researchers only successfully removed part of the chromosome, so now the "universal" cell "is not easy to throw rejection". TADA high that if you can remove all chromosomes, the quality of the "universal cell" will not bring rejection. Regeneration Medicine Institute in shi Xian-Fu said that this method does not use eggs, fertilized eggs, germ cells, and therefore to study using patients ' own cells to treat has opened up a new road.
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