Hemophilia, neuromuscular defect, Eastern Mediterranean anaemia, these innate genetic diseases to thousands of families brought untold suffering. However, in the near future, maybe just like inoculated, some early injection of hematopoietic stem cells, which is expected in the long lane will cure these diseases.
Shanghai Jiaotong University Professor of medical genetics Huang Shu frame led ABC, for the first time in the international arena to goat as animal model, the human umbilical cord blood hematopoietic stem cell injection to pregnancy 45-55 days of fetal goat celiac, success built to long-term survival of people/goat xenotransplantation chimera, xenotransplantation, antenatal treatment and tissue injury and so provides the theoretical basis and the new method. As the "tenth national 863 in stem cell areas of major projects, the results yesterday passed expert appraisal.
Stem cells, particularly in hematopoietic stem cell transplantation is an effective treatment method, for a variety of malignant diseases, hereditary diseases and autoimmune diseases, and injury, has broad application prospects. However, due to difficulties in finding appropriate matching, and transplantation of rejection, the stem cell therapy in clinical practice is quite limited.
This time, Huang Shu frame discussion group open a new use of intrauterine transplantation techniques that will stem cell transplantation in the time ahead of the fetal period. Due to fetal immune system is not the early maturity, for transplantation of allogeneic cells does not result in rejection.
Since 2000, Huang Shu research group began trying to frame in a b-guided, hematopoietic stem cells injected into the abdominal cavity of fetal goat is now the oldest accept transplantation of embryonic survival of the goat is 2 years. By tracing stem cells fluorescence markers, the researchers found that human derived stem cells in goat blood, liver, kidney, heart, muscles, lungs and other organs have a high percentage of distribution, and can differentiate into corresponding human tissues and cells, such as human liver cells.
On this basis, the scientists may in the future to human cells and animal cell separation, extraction of pure "belongs to the people" of the cell, and then to patients for cell therapy, or directly to the xenotransplantation human/animal chimeras as xenotransplantation of donor. At the same time, the human/animal chimera of organs is also expected to become a "pharmaceutical factory", through biological engineering technology for mass production of human proteins. You know, the only human liver cells can synthesize protein 4000 people.
Shortly afterwards, the group use the same way, on 12-day rat fetuses, and haematopoietic stem cell injection and thereby make the liver of mice damage was repaired. This suggests that stem cell transplantation in utero prenatal therapy and tissue repair has great potential.
It is worth mentioning, and easily raise ethical controversy of embryonic stem cell research is different, and haematopoietic stem cells belong to the adult stem cells, can only be differentiated into the organ of mature cells, thus avoiding the ethics of this sensitive issue. It is noted that the outcome of the related articles in internationally renowned journals the United States National Academy of Sciences College newspaper published.
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