World Science report () before a man-made, pure white, like milk, liquid, known as "carry oxygen treatment agent", it carries oxygen content is our own oxygen-carrying blood to 50 times. The researchers claim that this new product will be the main cause of death in the treatment of accidents — the best way to traumatic brain injury.
Just ate dinner with friends, grace · Leclerc, I got a make every parents are funky phone, on the other side of the phone is Virginia Medical School of the Ministry. "Your daughter has a serious accident, you have to go to Richmond. "At this point, Leclerc is Virginia's restaurant, to the 20-year-old daughter, Beth · Lam is the Richmond hospital receiving treatment at least two hours.
Beth · Lam friends recalled in March this year, the ins and outs of a traffic accident. Beth and friends riding bike from a steep hills careering-down, the front is busy crossroads. Meanwhile, Beth · Lam suddenly cry "brakes", she gave the press brake lock, but the wheel continues rotating rapidly, simply can not stop. Big hard head, her friend heart a meter, busy call "will soon turn into the car in front of the alley."
Although the alley just before the crossroads in front of the entrance, but since the speed is too fast, too late to turn the past Beth coming into the wall, the first is the head-strong field struck a concrete wall, unfortunately Beth did not wear helmets. She was taken to hospital by ambulance, became the head from injury of 150 million people in the United States.
The new "one blood" was born
Beth's mother was rushed to the Richmond hospital on the way at this point, the second phone rang, it was the doctor. Grace · Leclerc recalled: "the doctor says that my daughter was very seriously injured, if I agree that they will use a pilot, has not yet been United States food and Drug Administration-approved drugs, surgery for Beth immediately, where she lives. He told me that the drug will be able to increase the amount of oxygen in the brain. For me, only help to rescue you, so I immediately agreed. ”
The hospital in obtaining the permission of their parents ' oral Beth immediately after an application is known as "carry oxygen treatment agent" and "one blood" rescue Bess. Before this was only carry oxygen components of Virginia Commonwealth University teaching hospital for clinical trials. In animals test results indicate that this component makes the brain injuries reduce by half.
Researchers believe that this is because of its tiny particles can carry oxygen through the swelling, the damaged blood vessel, and we are not in the body of red blood cells and brain cell hypoxia is a major cause of brain injury.
Doctors then is to prove the above conclusions on the human body also apply. Including Beth, eight major accident victim, will participate in the oxygen carrying agent phase II clinical trial to further test "carry oxygen treatment agent" security and efficacy. If "carry oxygen treatment agent" in the subsequent test performed well, it will get the United States food and Drug Administration's approval, as in the treatment of traumatic brain injury in the first drugs.
In the United States and some frequent conflict countries such as Iraq, this kind of "one blood" will be able to show their talents.
"White blood" won the "red blood"
"Carry oxygen treatment agent" is the latest in artificial blood. About human blood substitute studies, early in the 19th century began, when the doctor even milk supplement loss of blood. In the early 1980s, under tremendous attack AIDS, research and development pharmaceutical companies vied with each other to resolve the artificial blood, because of the blood was infected, causing genetic blood donation of pressing need. The basic idea is to use the "person" instead of donating blood blood for transfusion in operation.
Two new products soon surfaced. A class is it red substitutes, in part by the person or an animal made of hemoglobin, a protein in the human red blood cells to carry oxygen; white substitutes, it completely by perfluorinated compounds (PFCs), and its chemical characteristics similar to PTFE non-stick pan. PFCs have very high gas and liquid oxygen, compatibility with line, so that blood can carry more than ordinary situations many times more oxygen than hemoglobin-based blood substitutes carry oxygen capacity faster and stronger than ever.
In the nineties in large clinical trial, researchers compare the artificial blood and real blood treatment effect, found that the use of artificial blood of patients with heart attack or a stroke of probability too high, the reasons to be attributed to design flaws, this test has also led many biotechnology companies have closed down.
After 20 years, spent $ 1 billion for research, the scientists received the most valuable lesson: artificial blood and blood really comparable. Blood circulation system is like a supply line for the whole body of various organs and tissues conveying nutrition, hormone and oxygen. When blood pressure is abnormal or and the fight against infectious diseases, blood circulation system or even overtime work, and the artificial blood will only be able to transport oxygen. But based on PFC blood substitute, the ability to transfer oxygen is very powerful, probably equivalent to our blood oxygen capacity of 50 times.
For this reason, blood substitutes, commonly called "oxygen treatment agent", and the vendor no longer use them for clinical trials.
In fact, the practical experience and strict screening, has donated blood is safe, people do not have to worry about blood bank has to carry the bacteria in the blood. Nevertheless, the hospital on a common, can carry oxygen liquid there is still great demand, especially on blood shortage of forces. So the United States military investment of at least $ 10 million to study blood substitutes, and looked forward to pharmaceutical companies can solve their problems.
Virginia Commonwealth University's doctors to "carry oxygen treatment agent" expect a large and widespread. If such a successful blood substitutes can win the United States military, military approved
Will help with the drug in clinical trials. In the near future, the doctors may be able to use "carry oxygen treatment agent" save more lives, at least this is one of hope.
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