Destruction of in vivo tumor cell breakthrough: "nano-worm" (map)

Keywords: in vitro and in vivo tumor cells "nano-worm"

Currently, the University of California, San Diego, Santa Barbara campus as well as the MIT scientists developed a nano-scale size of "nano-worm", it may not undermine the normal immune defense system of the human body at the blood flow in the parade, like a miniature missile to destroy the cancer "base" of the tumor cells.

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This study found published in this week's Edition of the journal of advanced materials, Nano-worm could not help but make people think of 1966 sci-fi film "magic voyage", in a submarine to narrow to microscope class size, and then this mini submarine scientists will injection into the blood, submarine destroyed a senior official of thrombosis in the brain. At present, the use of nano-worms physician will eventually be able to locate and remove general medicine methods it is difficult to detect small tumor cells. By loading eliminates tumor of special drugs, this ultra-Nano tools one can effectively delivered to the tumor on the human body with high concentration of toxic anti-cancer drugs, while other organs of the human body does not have a negative impact.

Leading the research of the University of California at San Diego biochemists Professor Michael? selles, said that "many of the nanoparticles are considered to be the body's protection mechanisms, it can in a few minutes to catch and remove the blood tumor cells. Reason why they have such a high productivity is due to its special shape and surface of aggregation in vitro tier enables Nano-worms can evade the body's mechanism of exclusion characteristic. Now this nano worms can cruise in the human body for several hours to search for work. ”

The research group, a member of the MIT health sciences and Technology Department of biology physician Sanger Tower? bohaty Prof. said, "when the surface Nano-worms, additional medication can improve the effectiveness of the drug, the tumor cells have a direct role in the eradication of destruction. This approach also reduces toxic anticancer drugs to normal tissue produces side effects, as well as on the tumor and abnormal lymph nodes and better diagnosis. ”

Scientists think that such a spherical iron worm connected together, like a worm fragments, can generate 30 nanometers long (normal length of 300 000 earthworm) viscous worm-like structure. Nano-worm iron oxide component can be used in diagnosis equipment illuminated, particularly advantageous for magnetic resonance imaging (MRI) device through the discovery of nano-worms to find human tumor cells. Selles, Nano-worm iron oxide component with the superparamagnetic characteristics of magnetic resonance imaging device is very bright. Each Nano worm has eight segments, these oxidation of iron magnetic magnetic pieces together will provide a greater observed signal. This allows better observation more tiny tumor cells, is expected to enable physicians to diagnose in early development stage of the cancer patient.

The aggregation of nano-worms in vitro tier is composed of dextran biocatalysts, scientists use in the treatment of tumor cells F3 peptide molecule coated in worms. F3 peptide molecule consists of University of California at Santa Barbara, Burnham Institute for medical research cell biologists Earl base? Rouse Latif Professor in the laboratory successfully developed, this peptide molecule can destroy tumor cells Nano worm places.

Schüssel said, "due to its elongated shape, Nano-worms can carry many F3 peptide molecules at the surface of the tumor cells, the combined effect of nano-worms can significantly improve the Nano to destroy tumor cells. ”

Scientists in their experiments on rats suffering from cancer of the blood-injection-worms, further examination of the Nano-worm can collection in tumor cells, they found that the nano can stay in the blood of the worm in a few hours. In Ussel laboratory participated in the study of materials science and engineering graduate guijo-Parker said, "this is an important characteristic, Nano-worm capable of longer stays in the blood, which increases the destruction against tumor cells. ”

Rouse tarati said, "we now use a new generation of intelligent Nano worms build tumor cells to destroy the Nano-devices, we hope that the future of this equipment will improve cancer diagnostics and treatment of cancer cells can be accurate. ”