Scientists find osteoclasts inhibitors

[/]: Japan Osaka University and the United States team recently stated that they were experimental in experimental rats, chemicals found in the attached to the bone surface suppression of osteoclasts can alleviate the symptoms of osteoporosis. Related article published on 8 February in the journal nature on the network.

Osteoclasts are cells that consists of more nuclear giant cells, 100 microns in diameter, mainly in the bone surface, intraosseous vascular channels around the functionality of the exercise of the bone resorption. Osteoclasts and osteoblasts corresponds to the function, both in collaboration with the development of the skeleton and play an important role in the process. But the researchers found when osteoclast activity too active but will lower bone density, causing rheumatism.

The group uses a special microscope observation of mouse bone internal circumstances found in the blood of a lipid (from fatty acids and alcohols effect generated ester and its derivatives, insoluble in water but soluble in fat soluble solvents) can play a role of osteoclasts. To suffer from osteoporosis mice implanted for osteoclastic bone surface separation from the pharmacy, the symptoms of bone fracture and not when compared to reduce injection medicament for nearly 60%. Osaka University Associate Professor Ishii-you said: "this finding may help to develop a response to new therapies for osteoporosis. There are already weakened osteoclast activity related to drug use, to be able to inhibit the attachment to the bone surface of drugs or can improve outcomes. ”

The International Osteoporosis Foundation's statistics show that osteoporosis is currently afflicting global about a third of women over the age of 50 and one-fifth of men over 50 years, has become a global public health problem. As the world population increases and the increase in life expectancy, the threat of this disease. With the acceleration of the process of ageing population, it is expected that Japan osteoporosis patients will be more than 10 million people.