SARS (SARS) in the treatment of newly discovered

Research has shown that a protein-angiotensin converting enzyme 2 (ACE2) caused by the SARS lung failure can play an important protective function, it can protect the body from acute lung failure and pulmonary edema. The results of this study not only of the SARS coronavirus, etc. caused by acute lung injury treatment indicate a new direction for the development of safety and reliability of the SARS coronavirus vaccine provides a scientific basis.

Research results are divided into two separate but interrelated research papers, published in the 7 July 2005, the natural law and 10 July in the journal Nature Medicine, Austria Academy of Sciences Biotechnology Institute white surf · penning Professor and Chinese Academy of medical sciences of basic medical sciences, Professor Jiang chengyu share the corresponding author.

This study by the Chinese Academy of medical sciences (pumc) of basic medical sciences, experimental zoology, Peking Union Medical College Hospital, and other units and Austria and other countries more than one lab, in collaboration with Professor Jiang chengyu laboratory of reorganization of the SARS coronavirus in spike protein S and its mutants and recombinant ACE2 and its mutants, and white surf · penning Professor, laboratory of ACE2 gene deletions mice work, on the basis of the SARS coronavirus analyzed the pathogenic mechanism.

Studies confirm that ACE2 is SARS coronavirus in vivo receptor. When the virus enters the body, it first and combination, led to ACE2 protein degradation, reduce the number of ACE2, the body which is compromised, the lungs, causing damage to lung failure and by regulating ACE2 eliminates SARS lung damage caused.

The study also found that SARS coronavirus spike protein S and ACE2 with fragment, in acute lung failure model can cause or aggravate lung injury. Removal or modification of this fragment to develop more secure and reliable prevention of SARS coronavirus vaccine provides orientation.

Acute lung failure is not only the death of SARS patients is sepsis, aspiration pneumonia patients, the cause of death and or avian influenza, famous in the early 20th century Spain influenza and potential biological terror factor of Bacillus anthracis lung infection caused by the main causes of death in patients.