Lincoln's DNA, what's the problem?

Build tall, thin, highly over 6 feet, slight stoop, long arm, with a disproportionately large hands.　　This is a journalist during the civil war through the eyes of Abraham · Lincoln. Lincoln is too big and not too coordinated signs are descendants of suspected as a hereditary diseases — the Marfan syndrome (MarfanSyndrome). This disease is approximately twenty thousand people in a case of occurs. Patients are mostly due to arterial rupture and sudden cardiac death, and are relatively small.　　Skeletal anomalies is one of a kind of performance. In 1962, a 7-year-old Los Angeles boy was diagnosed with this disease. Doctor began in his family to find genes found little boy is Mordecai Lincoln II · eighth generation disun, Mordecai II is a great-great-grandfather of President Lincoln.　　Although this finding does not prove that Lincoln had to carry the boy in the pathogenicity of the copy of the gene, but this is a very intriguing clues. The Lincoln's DNA and other adventures in genetics, "a book of opening, author Philip · R · Riley tells scientists trying to verify whether the DNA determine Lincoln with Marfan's syndrome.　　As the United States medical genetic Academy, he became the program's decision makers. The beginnings of modern genetics in 1865 monk Mendel's paper, which raised the genetic nature of the particles as well as the dominant and recessive trait. The beginning of the 20th century, the United States and Anatomy of the human family Rabbi reports dominant inheritance of the first example: a large family in about half of the members is congenital short means that finger than normal human staple.　　This family is a descendant of short means woman, has more than 4 generations, of which 36 people have this kind of "family finger." However, the description of Mendelian dominant inheritance and recessive genetic just genetic three models of the two. It also took some 50 years to figure out the third mode — sex-linked genetic or x-linked inheritance of scientific principles. It is well known that human genes on chromosomes respectively 23, of which 22 are autosomal, 1 on the sexual chromosomes. Female sexual chromosomes consists of two X chromosomes and males is a X chromosome and a Y chromosome.　　Sex-linked inheritance refers to the sex chromosomes genes, the genetic patterns and gender links exist. Marfan syndrome is autosomal dominant inheritance, was named to a France paediatricians. It is said that, in the human body the entire genome of around 10 million pairs of genes as long as a mutation causing Marfan's syndrome, other genes can reduce or exacerbate the impact of this catastrophe.　　Perhaps, Lincoln is a mild Marfan syndrome, big but still healthy. In 1991, three research group at reporter discovered the disease-causing genes.　　More importantly, on 28 clinically diagnosed as Marfan syndrome family study found that each of these lesions are on chromosome 15 fibrillin gene defects. This discovery led to Lincoln's DNA test. Even if the time flow, DNA double-strand, which breaking open even a short one fragment will bring important genetic information. At present, scientists have learned from very tiny tissue extraction and analysis of DNA technology.　　Maybe you only need a small block of Lincoln bone fragments, it is possible to obtain sufficient DNA. Today, genetic testing of the types and quantities are large expansion. Although abortion and other ethical controversy, but more people benefit from it. 37-year-old professional tennis player, his father died of Huntington's disease, this is a late onset, no dead slow fatal brain disease. He thought his helm, all day dining, "because tomorrow it will die."　　However, after testing, he is not the kind of genetic father, decided to start life from now on. On the other hand, the use of DNA in the treatment of human disease of the mind, namely, gene therapy becomes a reality. 1990, United States 4-year-old girl de Silva became the first gene therapy. She suffers from a rare autoimmune diseases. Doctors from her blood extraction for a large number of white blood cells, and then enter de Silva of the vein. 10 years later, de Silva life very well. Then Lincoln? in addition to the Marfan syndrome, he has also been suspected of hereditary depression. Throughout his life he suffered lots of pain, particularly in the child's death, after admission to the White House also has a son who died.　　However, even if not subjected to these, he also occasionally exhibit discouraged. Unfortunately, for various reasons, scientists have not been significant for experiments in Lincoln's DNA. Therefore, since we still don't know whether · Abraham Lincoln with Marfan's syndrome.　　He died at the age of 56, did not see the Marfan syndrome in obvious cases, maybe gene in his possession a mutation has occurred, but just show this kind of genetic diseases of mild disease. The Lincoln's DNA and other adventures in genetics "[United States] Philip · R · s Riley et Chung Yang translation Shanghai Science and technology education publishing