Intestinal pathogenic mechanism of perception explored

The innate immune Science Magazine Online Edition reports, the Japan Research Institute for microbial diseases, Osaka University Professor Tribunal Liang Jing men, who announced that they found small intestinal pathogens such as salmonella perception and stimulate the immune response mechanism.

The human body with the immune system to identify and exclude invasion of bacteria, viruses and parasites pathogens. Immune system is divided into the natural immune system and the immune system. The natural immune system capable of sensing bacteria, parasites, viruses and other pathogens invade after Defense reaction. Intestinal bacterial pathogens is perceived intrusion and immune response, but the immune system and does not attack the intestinal digestion and absorption of probiotics. Prior to this, the scientists found on intestinal pathogenic bacteria invasion of the mechanism is not fully understood.

Japan study group after animal found in cognitive pathogens, invasive organisms capable of sensing bacterial pathogens and other foreign bodies of the body's cell membrane surface protein-TLR (Toll-likereceptor) plays an important role in the family, where the "TLR-5" protein in intestinal perception when Utah pathogenic bacteria invasion. The research team found that some cells on the inside of the small intestine in large quantities "TLR-5" protein, timely sensing bacterial flagella contains elements which identify the pathogen, activate the immune reaction. This immune response to prevent bacterial infections in General. But the typhoid bacteria can enter the cell Interior, in turn, use the function enables TLR-5 typhoid salmonella diffusion. The research results for the first time understand the perception of pathogenic bacteria in the gut, and typhoid fever, on the development of mechanisms of bacterial enteritis, especially new treatments of typhoid fever.