[/]: Beijing time today (5 January) 1 am (London time 4, 18), the world's leading academic journals published online in the nature of Chinese scientists to a new study results, it reveals the insulin resistance and diabetes occurs for a new mechanism and to prompt a potential therapeutic method. This finding comes from Shanghai institutes for biological sciences, Chinese Academy of Sciences Institute of Biochemistry and cell biology is the study of the leadership of academician gang Pei group long-term scientific research results. Peer review of the journal nature that "this is a significant work."
Diabetes by the lack of insulin or tolerance, Division ⅰ and ⅱ type II diabetes, which accounts for about 90% of the total number of patients. And cannot be produced or only generate a small amount of insulin in patients with diabetes mellitus type I, type II diabetes is characterized by patients with insulin tolerance, that is, it can produce enough insulin, but the body's cells are unable to respond to it, thus causes the glucose metabolism disorders. Currently, the global diabetes in more than one Chinese 2.5 billion, more than 2000 million patients a year nearly 1 million, it is expected that by 2025 the number of Chinese diabetic, or approaching 40 million in the world.
Research has shown that the normal state, insulin can activate the muscles, liver and adipose tissue of insulin signaling pathway to achieve lower blood sugar function. But in patients with type II diabetes, the insulin in this important damage, muscle, liver and adipose tissue, and so on insulin sensitivity, produce insulin tolerance. Insulin resistance and diabetes onset, and heredity, obesity, and lifestyle factors related molecular mechanisms, but its still not clear.
The research group found that gang Pei human memory in a "Messenger", to protein and insulin "liaison". It has multiple functions of signaling proteins known as "β-end protein 2", it can be used with insulin receptors, forming a kind of "signaling complexes". "Protein messengers" as this signal complex structural core, is responsible for the "contact" in the upper reaches of the insulin receptor and is responsible for the "contact" downstream of kinase signaling molecules, both "coupling", thus contributing to the body's sensitivity to insulin to maintain normal glucose metabolism. The "level of" protein messengers or feature missing, lower so that it does not signal complex formation, a direct result of the insulin tolerance and disease. Gang Pei, etc. found in type II diabetic model mice, "β-end protein expression level 2", while significantly reducing artificial supplement this protein, which can effectively reduce insulin resistance in mice and their related symptoms.
Scholars believe that the study not only reveals the insulin resistance and diabetes occurs in the new mechanism, but also for related therapy provides a reference of a new policy, prompt "β-end protein 2" and its relationship to the insulin receptor complex, is expected to become the research and development of insulin resistance, metabolic diseases, new target for drugs. It is reported that this outcome has applied for patent.
The natural law journal peer review comments that this research reveals the β-arrestin (endless protein) many undiscovered important biological functions, the use of a series of genetically modified mice to study in vivo capabilities of these proteins, embodies the research depth and accuracy. This work is of great significance for insulin resistance area provides a totally new concept.
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