Scientists find gene causing breast cancer cell proliferation

Keywords: breast cancer cell proliferation gene

[/]: United States researchers said they found a gene called MTDH in breast cancer patients play a key role in the body, which increases the chances of cancer cell proliferation and resistant to chemotherapy. Concerned experts pointed out that the gene research and development of new drugs will have broad prospects. Related research results published in the March edition of the journal Cancer cells.

Prevent the spread of cancer cells is quite important. Research shows that the spread of the cancer cells without patient, more than 98% percent of patients survive for five years, while in the cancer cells have spread, only 27% of% of people will be able to survive.

United States Institute of New Jersey's cancer? Michelle Reis and Princeton University Hong bin (code) employs several methods to find the genes of cancer spread, they call a huge database of tumor cells and found suffering from serious breast cancer patients, their 8 human chromosome of a small part is repeated many times. In General, most normal DNA sequence of a gene only have 2 copies, but this part of the gene copy number of up to 8.

Next, researchers analyzed the mining from 250 patients with breast cancer gene samples for genetic variation among them. The study found that in rich attack tumors, MTDH gene hyperactivity or overexpression. The genes not only enables tumor cells closely attached to the incidence of blood vessels in the vicinity of the organs of the region, but also can significantly weaken the role of anticancer drugs to cancer cells to become drug resistant.

The researchers then injected in experimental rats were collected from the patient with the gene mutation, found in tumor cells of mice was being spread of cancer, these tumors can also suppress the traditional chemotherapy drugs such as paclitaxel for the treatment effect.

But when researchers on these tumors are genetic modification MTDH gene was suppressed, the proliferation of cancer cells no longer and there are no longer on chemotherapy. The researchers say, MTDH may include prostate cancer, and many other types of cancer also play a major role.

Researchers hope that their findings will contribute to the development of not only can stop the spread of cancer cells and treatment response better medicines.