Tuesday, December 14, 2010

Human B cell can become the AIDS virus

Technology channels (http:///) in message: United States researchers in Toronto, the 16th International AIDS Conference reported that they found in the AIDS virus attacks the body's immune cells T cells, the body of another type of immune cell B cells play AIDS virus "accomplices" role. AIDS virus mainly attack T cells, will first in T cell surface "foothold", and then mixed in and control of T cell. AIDS virus to enter the T cells is dependent on two molecular channel, a CD4 cell membrane molecules, is a x 4 or C5 molecular receptors. Previous studies have shown that T cells of the immune cells outside of the attack is not involved in the process.    But the researchers found that B cells through the synthesis of a protein called DC-SIGN, the AIDS virus attack T cells during play the role of "accomplices". University of Pittsburgh Professor infectious Rinaldo-led research team on 33 healthy people and 20 patients with AIDS adult of B cells. They found that if you use certain compounds blocking B cells DC-SIGN activity and B cells and T cells together into a dish, HIV cannot infect T cells. But once activated the activity, DC-SIGN HIV in T cells within 24 hours. Researchers also found that B cells also is likely to be infected with the AIDS virus T cells in the human body to live. When B cells in the T cells surrounding, the AIDS virus on T cells do not have much impact.    Researchers believe that this finding may help to explain why AIDS virus in human body hide dozens of years. T cells and B cells are part of a lymphocyte immune function. T cells produce antibodies, which is a direct function, its immune function called "cell".    B cells play a role by producing antibodies, antibody present in body fluids, so its immune function called "humoral immunity". At present the medical profession has no special treatment against AIDS. Rinaldo et al. 's view, to learn more about HIV attacks the immune cells of the process, help to curb AIDS virus found in the medical field.

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