People and other multi-celled animal tissues and cells must be continuously added in order to survive, so adult stem cells for their extremely important. Adult stem cells can differentiate into various types of cells in the body, while at the same time, they also want to keep "self." Humans and other animals of stem cells in life have as little to produce DNA mutation, or to make up for by DNA repair gene damage because the DNA damage is not only likely to affect the stem cells, and can even kill them aside.
In order to determine DNA damage and repair on the impact of adult stem cells from the Oxford University Professor Richard Cornall led international scientists on mouse bone marrow of hematopoietic stem cells. They found that the lack of DNA ligase ligase IV (an important DNA repair enzyme, or due to the oxidation of radiation caused by the rupture of the DNA Double Helix, hereinafter referred to as Lig4) mice, its DNA repair inefficient, hematopoietic stem cell DNA damage faster and faster, resulting in disappearance of a large number of stem cells.
Cornall said, "when we grow old, the body cells and other cells in the regeneration capacity gradually decline. But in the absence of mice Lig4, accelerated this process. ”
New discovery will undoubtedly enhance the people's understanding of the aging process itself. Cornall said: "the accumulation of DNA damage caused by the reduction of adult stem cells, is the primary mechanism of aging. At the same time, new discovery also means able to increase DNA damage caused by genetic and environmental factors may be the key to organizational aging speed the decisive factor. ”
In addition, new research results for medically adult stem cells for transplantation is also very important. Stem cell culture and transplantation of success, it probably depends on the frequency of DNA breakage and its repair status.
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