Cocktail therapy successfully suppress breast cancer lung metastasis

Photo caption: "cocktail" can make four genes "silence", thus preventing breast cancer cells in mice. (Picture source: Getty)

-Tech report [] message: according to the April 12 edition of the journal nature reported that United States scientists use the "cocktail" succeeded in inhibiting the metastatic cancer tumors in mice, and the treatment of two drugs already in use in human clinical, another has entered the experimental stage.

Cancer Metastasis is cancer one of the characteristics of the most terrible: 90% of deaths from cancer patients of cancer metastasis. However, the transfer procedure is difficult to explain — for example, two cancer looks exactly the same, but a will transfer to another does not. Cancer every day from vessels release hundreds of cancer cells, but only a very small part successfully in another place "some roots" into a new secondary cancer.

2005 New York Sloan Center for cancer research (the Memorial Sloan-Kettering Cancer Center) of Joan Massague team identified a series of breast cancer cells can lead to lung genes, one of the four is the EREG, MMP1, MMP2 and COX2.

The Group's latest findings further indicate that these four genes work together, you can speed up cancer metastasis. They are not only the "abduction" of vessels used for the primary tumor growth and help cancer cells "escape" into these vessels arrived in the lungs, and help them get through the capillary walls, the ultimate in foothold "Lung". While the use of several drugs to cocktail making these four genes "silence", can be quite effective in preventing cancer metastasis. But if one only inhibits a gene, the effect is not so obvious.