The Shanghai Institute of applied physics, libin, the researchers used a combination of "dynamic" nano dip pens can first enzyme "positioning to place" in a single DNA molecule chain, then by controlling the conditions of the enzyme reaction "lock" in the original location, thus making does not have the enzyme-specific enzyme can DNA chain specific parts for digestion.
Guest introduction, this single molecule Nano-positioning enzyme technology will contribute to the integration of "molecular surgery" and moving towards practical application.
A nanometer is one billionth of a metre, approximately equivalent to the people of a hair diameter of six thousand. The so-called "DNA" molecular surgery refers to nano-level on the implementation of a single DNA molecule "surgery". To complete the DNA single-molecules in incising, migration, and pickup, and so on "molecular surgery" feature, you can rely on AFM Nano-Probes of mechanical force. While the finer molecules surgery you will need to rely on Nano-positioning of single molecular and biochemical reaction.
Libin explains, this technology enables to implement finer molecules surgery possible.
This research work is the National Natural Science Foundation of China, the Chinese Academy of social science innovation important direction of the Fund and the Shanghai Science and Technology Fund, and the results of the United States chemical society journal published.
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