Technology channels () message: eliminate chronic pain usually has no special effect, but now scientists have found a blocking pain nerve signal delivery method. On a cold compress on the pain points of analysis let neurophysiology family found the treatment of chronic nerve pain of new mechanisms.
Edinburgh University scientists have proposed a new method for relieving pain, they are influenced by the ancient China and Greece medical and prescription of inspiration. This kind of therapy to those common access therapy invalid role for those diseases. And this up to millions of patients. This study published in the latest issue of the modern biology "(Current Biology).
This study is aimed at the role of pain cold compress and expand — both lower temperature, but also has a cooling effect of the substance, such as menthol. Cold compress methods have long known that the forthcoming cold pressed in touch the wound. The temperature decreases, vasoconstriction, this prevents redness. But why the cold compress can be on effective migraine and joint pain, this is a secret. England medical scientists successfully identify such mechanisms and recommend the use of small doses of drugs. In the meantime, the ways to avoid common Painkiller side effects.
Scientists noticed already known the fact that some skin nerve terminals including some receptors, they right temperature change and the food is very sensitive, such as "burning" sense of pepper and a "cool" in the sense of menthol. These sensors temperature sensors in the TRPM8 in temperature 8-12 ° c are active. At the same time similar substances icilin menthol is also able to activate this kind of sensors.
Edinburgh University scientists decided in mice of cold receptors and pain. Will initially focus on mouse leg tie up a thread, the mice continued to feel the chronic pain, and then enter icilin to the spinal cord. The control group is small tub wash for five minutes in a bath of cold water temperature drop, to 16 ℃ (researchers said this and common cold compress water temperature almost). After that the affected part touching the mouse. Then lost the mice to calm icilin accept pressure intensity than two times.
Common participation in the study of Fleetwood-Walker explained that due to the cold-sensitive receptors are activated, the spinal cord nerves Vassel has also received information, and blocking the other neural transmission of information on pain.
The researchers stressed that temperature reduction of information to be able to block the pain signal-even from other parts of the body from the signal — the fact that we did not know before. Fleetwood-Walker said, "we just observed in animals, certain nerve can control other nerves. ”
The researchers noted that suffer from chronic pain in patients with nerve damage in temperature sensors TRPM8 of higher levels. Common pain-killing drugs such as morphine
They also did not help. But there is no apparent common cooling effect, only the strict temperature interval on the TRPM8 sensors have a facilitating role. Scottish scientists said they way to let people suffering from arthritis and nerve injuries, spinal injury and neuralgia with life much easier. Only in the United States there are approximately 50 million people suffer from similar diseases.
Indeed, a new therapy to deal with chronic pain, severe pain is powerless.
The London Royal Academy of Brian · Kim led scientists team recently has also carried out similar work. They studied the temperature sensors TRPV1, it can send a signal to the temperature rise. In July of Physiology Association Conference, London, scientists announced that the hot compress can relieve pain, the pain-similar mechanism.
Commenting on the study of Scottish scientists, gold points out that scientists are only beginning to understand how to use the new data. He believes that in the temperature range for both the existence of analgesic potential. Fleetwood · Volcker next year can turn into clinical trials and human experiments.
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