Scientists photographed an important part of human DNA repair

[/]: University of California Davis researchers said they observed and photographed the human damage DNA is repaired during a critical phase, which will see Rad51 protein in complex and critical DNA repair process for its role in providing new information. Past research has shown that Rad51 protein associated with breast cancer.

The study, the responsible person is Professor of Microbiology at the University of California's famous Stephen · bucovat cobas base, he and molecular and cell biologists Ron · Baskin in 10 years ago and developed the use of fluorescent label elements and using light, capture a single DNA molecule. In 2006, the Division of the Watts branch gas Foundation and research team members to record a section of bacterial DNA damage repair process. However, in comparison with body DNA repair, bacterial DNA repair process is much simpler.

In real life, the body's DNA is constantly subjected to UV, tobacco, as well as a large number of natural and synthetic compounds and other harmful substances, and therefore suffer injury, induced cancer, cell death and mutations. However, when DNA damage, the specific protein in the human body and enzymes will be mobilized to repair operations.

Rad51 protein in damaged DNA repair operation has played a critical role in cell always on standby. Rad51 protein when working with molecular damage or faults along DNA composition of those long filaments that help enhance DNA spiral structure at the same time spiral structure and chromosome fragments of the second copy, while the second copy of chromosome as the reorganization of the template. Because Rad51 protein are associated with breast cancer gene BRCA2 control, so it is inferred that the protein inhibits breast cancer have the appropriate role.

With the fluorescent protein identification technology, real-time observation and shooting to Rad51 protein forming independent filament, and gained a new found. For example, they found and bacterial DNA repair damaged Rad51 protein than fine wire and not be infinite growth. This section of the Watts branch gas Foundation, there has not been proved by the described mechanism controlling the growth of the protein. In addition, the human body and bacterial DNA repair damage in another notable difference is that when a DNA repair is completed, the Rad51 protein does not naturally leave DNA; on the contrary, it needs to be removed from.

The researchers indicated that from a practical standpoint, the new observation and photography of single cell capacity provide the opportunity to obtain more information. Now, people can quantitative measurement of DNA repair process.